| 摘要 |
<p>Catalytic asymmetric hydrogenation of the Z geometric isomer of a compound of the formula wherein R and R1 each independently represent substituents as desired in the hydrogenation product or its derivatives, R2 represents -CN, , or -?-O-R6 wherein R4 and R5 each indepenently represent hydrogen, alkyl having from 1 to 5 carbon atoms or aryl, R6 represents hydrogen, alkyl having from 1 to 5 carbon atoms, aryl or an alkali metal, and R3 represents -?-O-R7 or-?-R8 wherein R7 and R8 each independently represent alkyl having from 1 to 5 carbon atoms or aryl; provided that, when R3 is-?-R8, R2 cannot be -?-O-R6 or , in the presence of a homogenous, coordination complex catalyst comprising rhodium, iridium or ruthenium in combination with an optically active bis phosphine ligand provides an outstanding level of optical purity.</p> |
