发明名称 |
UN PROCEDIMIENTO PARA LA PRODUCCION DE CEFALOSPORINAS. |
摘要 |
<p>In the preferred embodiment of the present invention trimethylsilyl 7-trimethylsilyloxycarbonylaminodecephalosporanate was prepared by bubbling dry carbon dioxide into an anhydrous solution of trimethylsilyl 6-trimethylsilylaminodecephalosporanate and found to be a useful intermediate in the production of cefadroxil and cephalexin by its acylation in anhydrous media with the appropriate 2-phenylglycyl chloride hydrochloride. Other cephalosporins are produced by acylation of 7-trimethylsilyloxycarbonylaminoceph-3-em-4-carboxylic acids or esters having a variety of substituents at the 3-position.</p> |
申请公布号 |
ES486463(D0) |
申请公布日期 |
1981.01.16 |
申请号 |
ES19630004864 |
申请日期 |
1979.11.29 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
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分类号 |
C07D501/04;C07D501/06;C07D501/18;C07D501/20;C07D501/22;C07F7/10;C07F7/18;(IPC1-7):07D501/22;61K31/545 |
主分类号 |
C07D501/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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