7ALPHA-SUBSTITUTED CEPHALOSPORIN COMPOUND

摘要

NEW MATERIAL:A 7alpha-substituted-7-cyanomethylthioacetylamino-3-( 1-methyl-1H- tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid expressed by formula I [R represents (substituted) aryl or lower alkyl], salts or esters thereof. EXAMPLE:7-Cyanomethylthioacetylamino-7alpha-(4-methylphenyl)thio-3-( 1-methyl-1H- tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid expressed by formula II. USE:An intermediate for producing cefmetazole. PREPARATION:A 7alpha-substituted-7-amino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl- 3-cephem-4-carboxylic acid (salt) or ester expressed by formula III is reacted with cyanomethylthioacetic acid (reactive derivative).