| 摘要 |
Aminoalkylbenzene derivative of the formula: …<CHEM>… wherein… A is oxygen or sulfur;… Y is oxo, thioxo, or cyanoimino;… a is an integer of 1 to 3;… b is an integer of 0 to 3;… c is an integer of 1 to 4;… R<1> is alkyl;… R<2> is hydrogen or alkyl; or… R<1> and R<2> taken together represent pyrrolidinyl;… R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: …<CHEM>… wherein… R<3> is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy;… R<4> is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; or… R<3> and R<4> taken together represent alkylidene or aralkylidene;… with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents and their acid addition salts being useful as histamine H2 blockers, especially peptic ulcer remedies. |
