Sulfonamido-benzoic acid derivatives

摘要

The invention relates to novel sulfonamidobenzoic acid derivatives having the general formula <IMAGE> wherein R1 denotes a C1-4 alkoxy group or a hydrazino group or an NR4R5 group, wherein R4 and R5 denote each a hydrogen atom or an identical or different C1-4 alkyl group; furthermore R4 may denote an aralkyl or substituted aralkyl group provided that R5 denotes a hydrogen atom; furthermore NR4R5 may denote a morpholine or piperazine ring; R2 and R3 may denote each a hydrogen atom or an identical or different C1-4 aliphatic group; furthermore R2 may denote a cycloaliphatic, aralkyl, substituted aralkyl or amino group provided that R3 denotes a hydrogen atom; furthermore R2 and R3 may denote together with the adjacent nitrogen atom a morpholino ring, an unsubstituted piperazine ring or a substituted piperazine ring, and to their pharmaceutically acceptable acid addition salts. Furthermore, the invention relates to a process for preparing these compounds. The novel sulfonamidobenzoic acid derivatives having the general formula I possess significant tyrosine-paralyzing activity and thus they retard the biosynthesis of noradrenaline.