发明名称 |
Benzodiazepine derivatives and process of making them |
摘要 |
1,4-Benzodiazepin of the formula <IMAGE> I wherein R is a low molecular straight or branched alkyl and X is halogen or trifluoromethyl, and pharmaceutically acceptable acid addition salts of these benzodiazepins. The benzodiazepins are made by heating an acyldiamine in the presence of phosphorus oxychloride at the latter's boiling point followed by reacting the resulting mixture of 7-member and 8-member compounds with an alkali metal alkoxide.
|
申请公布号 |
US4244869(A) |
申请公布日期 |
1981.01.13 |
申请号 |
US19780888151 |
申请日期 |
1978.03.16 |
申请人 |
KALI-CHEMIE A.G. |
发明人 |
MILKOWSKI, WOLFGANG;BUDDEN, RENKE;FUNKE, SIEGFRIED;HUESCHENS, ROLF;LIEPMANN, HANS-GUENTHER;STUEHMER, WERNER;ZEUGNER, HORST |
分类号 |
C07C233/12;C07D243/16;C07D245/06;(IPC1-7):C07D243/16;C07D243/24 |
主分类号 |
C07C233/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|