发明名称 Inhibitors of mammalian collagenase.
摘要 <p>Mammalian collagenase is inh<Image id="ia01" he="6" wi="21" file="IMGA0001.TIF" imgContent="character" imgFormat="TIFF" inline="yes" />ing the formula <Chemistry id="chema01" num="0001"><Image id="ia02" he="17" wi="40" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and salts thereof, wherein <UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sub>1</Sub> is hydrogen or alkanoyl of 2 to 10 carbon atoms;</ListItem><ListItem>R<Sub>2</Sub> is hydroxy, amino, or <Chemistry id="chema02" num="0002"><Image id="ia03" he="8" wi="30" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>R<Sub>3</Sub> is hydrogen, alkyl of 1 to 4 carbon atoms, <Chemistry id="chema03" num="0003"><Image id="ia04" he="8" wi="22" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or <Chemistry id="chema04" num="0004"><Image id="ia05" he="10" wi="27" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>R<Sub>4</Sub> is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and</ListItem><ListItem>m is 0 or an integer of 1 to 9.</ListItem></UnorderedLists></p>
申请公布号 EP0021766(A2) 申请公布日期 1981.01.07
申请号 EP19800302024 申请日期 1980.06.16
申请人 E.R. SQUIBB & SONS, INC. 发明人 SUNDEEN, JOSEPH E.;DEJNEKA, TAMARA
分类号 A61K31/095;A61K31/195;A61K38/00;A61P43/00;C07C51/08;C07C51/367;C07C51/377;C07C51/58;C07C67/00;C07C313/00;C07C319/18;C07C319/20;C07C323/52;C07C323/60;C07C325/00;C07C327/20;C07C327/32;C07K1/113;C07K5/02;C07K5/06;C07K14/81;(IPC1-7):07C149/20;07C103/52;07C153/09;61K31/19;07C149/23;61K31/22;07C149/437 主分类号 A61K31/095
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