| 摘要 |
HOE 9D/5 018 p-Acylaminophenoxycarbamates and Derivatives This invention relates to p-acylaminophenoxycarbamates having the formula where R1 and R2 are each independently hydrogen, loweralkyl, aryl and arylloweralkyl; R3 is hydrogen, loweralkyl, arylloweralkyl; R4 is hydrogen, loweralkyl, formyl, alkylcarbonyl, arylloweralkyl, phenylcarbonyl, arylloweralkylcarbonyl, substituted phenylcarbonyl, pyridylcarbonyl, and substituted pyridylcarbonyl with the proviso that if R4 contains a carbonyl group directly attached to the oxygen of the N-O moiety, R3 cannot be hydrogen; or R3 and R4 taken together form a heterocyclic ring selected from the group consisting of imidazole or loweralkylimidazole; X is hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; and p is an integer selected from 0 and 1; the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics.
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