PROCESS FOR THE PRODUCTION OF (1,1-DITHIEN-(3)-YL-1-HYDROXY-(3)PROPYL)-(1-PHENYL-1-HYDROXY-(2)- PROPYL)-AMINE AND (1,1-DITHIEN-(3)-YL-(1)-PROPEN- (3)-YL)-(1-PHENYL-(2)-PROPYL)-AMINE

摘要

The present invention provides a process for the production of 1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl!-1-phenyl-1-hydroxy-(2)-propyl !-amine, which comprises condensing thien-(3)-yl lithium with a .beta.-halogen propionic acid alkyl ester corresponding to the formula II in which R is a lower saturated aliphatic alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50.degree.C, after which the resulting compound corresponding to the formula III in which Hal is chlorine, bromine or iodine, is reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound.