ANALOGIFREMGANGSMAATE TIL FREMSTILLING AV NONAPEPTIDAMIDER MED LH-RH AKTIVITET

摘要

The novel nonapeptide amide derivatives of the formula (Pyr)Glu-His-Trp-Ser-R1-R2-R3-Arg-Pro-NH-R4 wherein R1 is Tyr or Phe; R2 is D-Leu, D-Ile, D-Nle, D-Val, D-NVa, D-Abu, alpha -Aibu, D-Phe, D-Phg, D-Ser, D-Thr or D-Met; R3 is Leu, Ile or Nle and R4 is alkyl of 1 to 3 carbon atoms which may be substituted with hydroxyl group have a strong ovulation inducing activity.