PROCESS FOR PREPARING CYCLIC PEPTIDE NUCLEUS

摘要

wherein R<1> is H or OH and; when R<1> is H, R<2> is H and R<3> and R<4> are both H or both OH, and when R<1> is OH, R<2> is H, R<3> is OH or C1-C6 alkyloxy and R<4> is OH, or R<2> is -@-NH2 and R<3> and R<4> are both OH, and the acid addition salts thereof. Cyclic peptide nuclei for formula 1 are prepared by the enzymatic deacylation of an appropriate antibiotic using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. NRRL 12052. The cyclic peptide nuclei and the salts thereof are useful intermediates in the preparation of new semi-synthetic antifungal agents.