| 摘要 |
<p>Synthetic compounds of the formula: are disclosed wherein X is an integer of at least 0 and A and B each represent a divalent moiety of the formula: wherein R1 and R5 are each selected from the residue of an amino acid or a polypeptide; R2 represents the residue of tryptophan or tyrosine; R3 represents the residue of an amino acid; R4 represents the residue of Iysine; arginine or histidine; a is an integer of 0 to 4, inclusive; b and c are each integers of at least 0: m is an integer of from 0 to 1, inclusive; and n is an integer of at least 1; provided that when R1 or R5 is the residue of a polypeptide, the corresponding b or c is 1. The disclosure is also of intermediate compounds for preparing the compounds of the above formula and derivative compounds having biological activity. Disclosed also are pharmaceutical compositions wherein the essential active ingredient is a synthetic compound of the invention and methods of using them for the prevention, suppression, treatment and diagnosis of multiple sclerosis.</p> |
