PARENTRAL FORMULATION WITH EXTENDED ACTION AND METHOD FOR ITS PREPARATION

摘要

The parentheral drug is used in veterinary practice. It extends the action of the active substance to seven days upon bio-compatibility with the human body. In effect, these are bio-disintegrating microspheres that are between 1 to 200 mkm in size. They are made of denaturated beef serum albumen and 9 α-fluoro-16 α-methylprednisolone in proportion of 10/0.5 to 10/2 weight parts. The method includes mixing of the water albumen suspension and 9 α-fluoro-16 α-methylprednisolone in oil phase in proportion of 1/100 to 10/100 vol. parts at 100 to 1,500 degrees C and mixing until full albumen meshing and infiltration.