Phenyl-piperazinyl-ethyl indanyl-propionate ester(s) - useful as analgesics having low toxicity

摘要

2-(5-Indanyl)propionate esters of formula (where R 2 Et or i-Pr) (I) and their acid-addn. and quat. ammonium salts are new. (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III) (where Q is OM (M = metal) and Z is CH2CH2Y (Y=halogen), or Q is halogen and Z is CH2CH2OH or Q is OCH2CH2Y and Z is H). (I) have analgesic activity and low toxicity, e.g. (I,R=Et) has an analgesic ED50 of 4 mg/kg (p.o. mouse) and a LD50 of >512 mg/kg (i.p. mouse).