发明名称 |
2-(O-Hydroxyphenyl)-pyrrole and process for its preparation |
摘要 |
2-(o-Hydroxyphenyl)-pyrrole and a process for its preparation, wherein o-benzyloxybenzoic acid allylamide is reacted with phosgene in an inert solvent, the resulting imide-chloride is cyclized in the presence of a strong sterically hindered base and the benzyl protective group is then removed by hydrogenolysis. 2-(o-Hydroxyphenyl)-pyrrole is a valuable intermediate for the synthesis of drugs. In particular, alkylamino-hydroxypropyl ethers thereof can, because of their beta -sympatholytic actions, be used for the treatment of coronary cardiac diseases, cardiac arrhythmias and hypertonia.
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申请公布号 |
US4240964(A) |
申请公布日期 |
1980.12.23 |
申请号 |
US19790064906 |
申请日期 |
1979.08.08 |
申请人 |
BASF AG |
发明人 |
ENGEL, NORBERT;FRANKE, ALBRECHT;FRICKEL, FRITZ-FRIEDER;KOENIG, HORST;STEGLICH, WOLFGANG |
分类号 |
C07D207/32;C07D207/333;(IPC1-7):C07D207/44 |
主分类号 |
C07D207/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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