| 摘要 |
A nitrosourea compound of the formula: <IMAGE> wherein R1 is an alicyclic group having 3 to 6 carbon atoms, phenyl, phenyl substituted with one to substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy and nitro, or a heteromonocyclic group selected from oxiranyl, tetrahydrofuryl, 1,3-dioxolanyl, 1,4-dioxanyl, morpholino, tetrahydro-S,S-dioxo-thienyl, furyl, thienyl and pyridyl; R2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl or O-aldo-hexopyranosyl-(1->4)-aldo-hexopyranosyl; and A is a single bond or straight or branched alkylene having one to 3 carbon atoms, is prepared by nitrosation of a compound of the formula: <IMAGE> wherein R1, R2 and A are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent however, effectiveness in human beings has not yet been demonstrated.
|
