14-Amino derivatives of morphine, methods of making them and analgesic compositions containing them

摘要

Novel derivatives of morphine having the general formula: <IMAGE> (1) wherein R2, R3, R4, R5 and R6 are certain specified values, and their pharmaceutically acceptable salts. The compounds exhibit activity in the central nervous system and may be presented in the form of pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable diluent or carrier.