ANALOGIFORFARANDE FOR FRAMSTELLNING AV DERIVAT AV TIENO(3,2-F)-S-TRIAZOLO(4,3-A)(1,4)DIAZEPIN

摘要

1456162 Thienodiazepines F HOFFMANNLA ROCHE & CO AG 7 Feb 1974 [8 Feb 1973] 05396/76 Divided out of 1456161 Heading C2C Compounds of the general formula (R 1 = halogen, NO 2 , NH 2 , alkanoyl; R 2 = pyridyl or thienyl optionally substituted adjacent to linking position, phenyl, o-trifluoromethylphenyl, o - halophenyl, o,o1 - dihalophenyl, o - nitrophenyl; R 3 = H, OH, alkoxycarbonyl, alkanoyloxy; R 4 = H, alkyl, alkanoyl, hydroxyalkyl, mercaptoalkyl, alkoxycarbonyl, aminocarbonyl, haloalkyl, alkoxyalkyl, alkylthioalkyl, aralkoxyalkyl, cyanoalkyl, alkoxycarbonylalkyl, alkoxycarbonylaminoalkyl, alkylcarbonyloxyalkyl, aminocarbonyloxyalkyl, dialkylaminocarbonyloxyalkyl, CN, alkyl NR 5 R 6 , COO alkyl NR 5 R 6 , CONH alkyl NR 5 R 6 ; R 5,6 = H, alkyl, hydroxyalkyl or NR 5 R 6 = monocyclic saturated 5-6 membered ring optionally containing an oxygen or further nitrogen atom ; n = 0, 1) are prepared by standard methods, e.g. condensing the corresponding 5- aryl - 1,3 - dihydro - 2H - thieno[2,3-e] - 1,4- diazepine-2-thione with R 4 CONHNH 2 .