1-Phenylalkyl-4-piperidyl-2-imidazolinone derivs. - useful as analgesics without addictive side effects

摘要

1-(1-Phenylalkyl-4-piperidyl)-2-imidazolinones of formula (I) and their acid-addn. salts are new. In (I) R is H or Me; R1 is H, 1-3C alkyl, phenyl or 2-4C alkanoyl; Ar is phenyl opt. mono- or polysubstd. by halogen, CF3, NO2, NH2, 1-3C alkyl, 1-3C alkoxy or 2-4C alkanoylamino; n is 0-3. (I) are powerful analgesics without addictive side-effects. Specific (I) is 1-(1-(2-p-tolylethyl)-4-piperidyl)-2-imidazolinone.