ETHANOLAMINE DERIVATIVE

摘要

The invention provides compounds of the general formula (I) and physiologically acceptable salts and solvates thereof, wherein Z represents the group where A represents a group selected from HOR<3>-, R<6>NH(CH2)p-, R<1><0>R<1><1>N-, R<1><2>OCH2-, CH3SO2CH2- or NCCH2-; where R<3> is a C1-3alkylene group, R<6> is a group selected from R<7>CO-, R<7>NHCO-, R<7>R<8>NSO2- or R<9>SO2-, and p is zero or 1, R<7> and R<8> each represent a hydrogen atom or a C1-3alkyl group, R<9> is a C1-3alkyl group, R<1><0> and R<1><1> each represent a hydrogen atom or a C1-4alkyl group or, when R<1><0> is a hydrogen atom, R<1><1> may also be a C1-4alkoxycarbonyl group, and R<1><2> is a C1-3alkyl group; where one of R<4> and R<5> is a hydroxy group and the other is a hydrogen or halogen atom or a hydroxy group; where A<1> is either a chlorine atom or a -CF3 group; X represents a bond or a C1-7alkylene, C2-7alkenylene or C2-7alkynylene chain, and Y represents a bond, or a C1-6alkylene, C2-6alkenylene or C2-6alkynylene chain, with the proviso that the sum total of carbon atoms is X and Y is 2 to 10; R represents a hydrogen atom or a C1-3alkyl group; R<1> and R<2> each represents a hydrogen atom or a C1-3alkyl group; with the proviso that the sum total of carbon atoms in R<1> and R<2> is not more than 4; Q represents a pyridyl group optionally substituted by one or two substituents selected from halogen atoms or hydroxy, C1-3alkyl or C1-3alkoxy groups, or Q represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms or the groups C1-6alkyl, nitro, -(CH2)qR<1><3> or -O(CH2)rR<1><4>, or Q represents a phenyl group substituted by an alkylenedioxy group of formula -O(CH2)tO-; where R<1><3> represents hydroxy, C1-6alkoxy, cyano, -NR<1><5>R<1><6>, -NR<1><7>COR<1><8>, -NR<1><7>SO2R<1><9>, -COR<2><0>, -SR<2><1>, -SOR<2><2> or -SO2R<2><2>; R<1><4> represents hydroxy or C1-4alkoxy; R<1><5> and R<1><6> each represent a hydrogen atom or a C1-4alkyl group or -NR<1><5>R<1><6> forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -O- or -S- or a group -NH- or -N(CH3)-; R<1><7> represents a hydrogen atom or a C1-4alkyl group; R<1><8> represents a hydrogen atom or a C1-4alkyl, C1-4alkoxy, phenyl or -NR<1><5>R<1><6> group; R<1><9> represents C1-4alkyl, phenyl or -NR<1><5>R<1><6>; R<2><0> represents hydroxy, C1-4alkoxy or -NR<1><5>R<1><6>; R<2><1> represents a hydrogen atom or a C1-4alkyl or phenyl group; R<2><2> represents a C1-4alkyl or phenyl group; q represents an integer from 0 to 3; r represents 2 or 3; and t represents 1 or 2. The compounds have a stimulant action at beta 2-adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.