摘要 |
Title compds. (I, A = S or -SO-; R = C1-3 alkyl), useful as protozoaides, were prepd. by reacting nitro-imidazole(II; X = halogen, acyloxy, acryloxysulfonyloxy) and phenol(III; Y = H, alkaline metal ion or ammonium) or by alkylating nitroimidazole(IV) or by oxidizing I(A = S) to I(A = -SO-). Thus, 4-methylmercapto-phenol of 1-1:1-methyl-2-(4-methylthiophenyl-oxyethyl)-5-nitro-imidazole dissolved in DMF, powdered K2CO3 and 1-methyl-2-chloromethyl-5-nitro-imidazole were mixed under 35≦̸C to give 1-methyl-2-(4-methylthiophenyl-oxymethyl)-nitro-imdazole(m.p. 116≦̸C).
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