PROSTAGLANDIN DERIVATIVES

摘要

of The Disclosure Prostaglandin type compounds of the formula where X is CH2-CH2, CH=CH is or C?C; Y is CH2 or 0; Q is 0 or(CH3)2C; Z is H, OH, CH3 or CH2OH and R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms, are prepared by essentially a one-step reaction from a new intermediate of the formula where R represents a linear, branched or cyclo alkyl group of 3 to 7 carbon atoms; Q is O or (CH3)2C; P is a removable protective group; Z is H, OP,CH3 or CH2OP and R' is H. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.