5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

摘要

Benzimidazole derivs. of formula (I) and their optical antipodes when A = B = H, and their physiologically acceptable salts with organic or inorganic acids are new: (A and B are each H, or together make a double bond; R1 = H, CF3, 1-11C alkyl, 3-7C cycloalkyl, OH or SH (both opt. etherified with 1-6C alkyl), phenyl (1-3C) alkyl, or phenyl (opt. substd. by 1-3 same or different halo, 1-4C alkyl, 1-6C alkylsulphinyl, OH or SH, both the latter opt. etherified with 1-6C alkyl); R2 = H, 1-5C alkyl, 3-6C cycloalkyl or phenyl (1-3C) alkyl; R3 = 1-6C alkyl). (I) have antiviral, interferon-inducing, ulcer-inhibiting and esp. cardiovascular (cardiotonic, hypotensive and/or antithrombotic) activities.