Cyclic double hemiacetals of enediol compounds and compositions and methods for preparing and using same

摘要

Novel chemical compounds of the general formulae: <IMAGE> +TR <IMAGE> wherein R1 and R2 are hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein R3 through R10 are hydrogen, alkyl, or aryl, wherein R5 and R6 together may form =0, and wherein X is hydroxy. The compounds are prepared by mixing specified amounts of a dialdehyde, alpha -keto-aldehyde, or diketone, such as methylglyoxal or a related compound, and an enediol, such as L-ascorbic acid or a compound that can be converted into an enediol, such as an acyloin, and allowing same to react under a nitrogen atmosphere in the presence of a non-interfering solvent. Compositions containing these novel compounds exhibit cytostatic, hypotensive and analgesic properties and are useful in the treatment of cancer in animals and humans.