PROCESS FOR PREPARING 1-TERT.-BUTYLAMINO-3-(2,5- DICHLOROPHENOXY)-2-PROPANOL

摘要

The invention relates to a process for the preparation of racemic and optically acbive 1-tert.-butylamino-3-(2,5-dichlorophenoxy)-2-propanol and its acid addition salts wherein racemic or optically active 1,2-epoxy-3-(2,5-di-chlorophenoxy)-propane is reacted in an apolar medium in the presence of tin(IV)-chloride with an N-tert.-butyl-formimidic acld alkyl ester, followed by adding to the reaction mixture an alkanol containing hydrochloric acid. The process affords in a simple and rapid way and in high yields a product which is directly usable for therapeutic purposes.