发明名称 |
ENHANCEMENT OF IMMUNITY BY INTRANASAL INOCULATION OF IL-12 |
摘要 |
<p>The present invention relates to a method of enhancing an immune response to a pathogen in a host using intranasal administration of interleukin-12 (IL-12). In one embodiment, the present invention relates to a method of inducing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In another embodiment, the present invention relates to a method of enhancing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In a particular embodiment, the present invention relates to a method of inducing an immune response to a mucosal pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of inducing a Th1-like immune response to a pathogen in a host, comprising administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. The present invention also relates to a method of enhancing a mucosal immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen.</p> |
申请公布号 |
WO9944635(A1) |
申请公布日期 |
1999.09.10 |
申请号 |
WO1999US04678 |
申请日期 |
1999.03.04 |
申请人 |
THE MEDICAL COLLEGE OF OHIO;METZGER, DENNIS, W.;ARULANANDAM, BERNARD, P. |
发明人 |
METZGER, DENNIS, W.;ARULANANDAM, BERNARD, P. |
分类号 |
A61K9/00;A61K38/00;A61K39/002;A61K39/02;A61K39/12;A61K39/145;A61K39/39;A61P31/00;A61P33/00;A61P37/04;(IPC1-7):A61K39/39 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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