摘要 |
The invention relates to a process for making propargylic alcohols by zinc-mediated catalytic, asymmetric addition of acetylenes to aldehydes. The compounds prepared are represented by formula : and the reaction is conducted in the presence of a chiral ligand. In the above formula R 1 is opt. substituted aryl, alkyl, alkynyl, alkylsilyl ester or ether; R<SP>2</SP> is opt. subsituted aryl or C 1-6 alkyl. |