GENETICALLY ENGINEERED CELLS AND TISSUES

摘要

The present invention relates to cells genetically engineered to express a target gene in response to a given "environmental cue" or "stimulus", and their use for the production of three-dimensional tissues or injectable preparations which can be used in tissue repair, replacement or enhancement, and/or for the delivery of therapeutic gene products in vivo. In particular, the invention relates to cell and tissue bioreactors that are engineered to express a target gene product, which acts as a reporter of a chosen physiological condition, augments deficient or defective expression of a gene product or provides an anti-viral, anti-bacterial, anti-microbial, or anti-cancer activity in response to a given "environmental cue" or "stimulus".