| 摘要 |
NEW MATERIAL:The title compound of formula I [R<1> is H, formula II (R<3> is H or lower alkanoyl group); R<2> is lower alkanoyloxy group; etc.; -A- is -(CH2)n- CHR<6>-(R<6> is H, etc.; n is 1 or 2), or formula III]. EXAMPLE:7-[ 2-( 6,7-Dihydro-1-oxo-1H,5H-benzo[ ij ]quinolidine-2-carboxamido )- 2-phenylacetamido]-3-( acetyloxymethyl )-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene- 2-carboxylic acid. USE:An antibacterial effective against Gram-positive and Gram-negative bacteria, with low toxicity, and capable of showing antibacterial actions on bacteria resistant to streptomycin. PROCESS:A compound of formula 10 (R<9> is lower alkyl group; X<2> is halogen) is reacted with a cephaloglycine of formula 11 to give the compound of formula I. |
