| 摘要 |
PURPOSE:The title pharmaceutical preparation capable of releasing a stable amount of theophylline gradually for a long period of time, being administered in an effective amount without causing side effect, comprising a specific ratio of theophylline, a metal salt of a higher fatty acid, and ethyl cellulose. CONSTITUTION:A prolonged granule of theophylline in the weight ratio of theophylline to a metal salt of a high fatty acid (e.g., calcium stearate) of 1:1-1:3, consisting of 10-45wt% of theophyllene, 30-60wt% of the metal salt of a higher fatty acid and 0.5-10wt% of ethyl cellulose. When the blending ratio of the metal salt and ethyl cellulore increases, the eluation rate of theophylline becomes lower, and when the blending ratio decreases, the eluation rate becomes higher. The prolonged granule can be administered to chronic asthma patients in every fixed amount stably for a long time, the effectiveness of the drug is prolonged, and side effect can be prevented. |
