| 摘要 |
PURPOSE:To obtain the title substance useful for preparing antibiotic amikacin, by forming a complex from an aminoglycoside antibiotic, e.g. kanamycin, gentamicin, or sisomicin, with zinc cations, and by acylating the complex. CONSTITUTION:An aminoglycoside antibiotic consisting of deoxystreptamine having an 3-aminoglycosyl or 3-alkylaminoglycosyl group at the 6-position, e.g. a compound of the formula (R<1> is OH or NH2; R<2> and R<3> are H or OH; R<4> is OH, NH2, or 1-4C alkylamino group), is reacted with zinc cations to form a zinc complex. The amino group without forming a complex bond with zinc is acylated and protected to remove the zinc, and the title substance is obtained. The complex bonds are formed at amino and OH groups at positions different from the well-known Ni, Co, Cu, or Cd cations, and various antibiotics can be obtained by introducing the desired acyl group into the amino group at the 1-position after removal of zinc cations. |
