| 摘要 |
<p>A series of novel 3-(substituted methyl)-2-oxo-1-benzimidazolinalkanoic acids of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="20" wi="57" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and the lower alkyl esters and unsubstituted amide derivatives thereof, and the base salts of said acids with pharmacologically acceptable cations, wherein X is hydrogen and X' is hydrogen, fluorine, chlorine, bromine, lower alkyl or lower alkoxy; or X and X', when taken separately, are each chlorine, lower alkyl or lower alkoxy, and when taken together are -QCH<Sub>2</Sub>(CH<Sub>2</Sub>)<Sub>n</Sub>O- wherein n is zero or one; Y is alkylene having from one to three carbon atoms arranged in a straight or branched chain; and Z is naphthylmethyl, furfuryl, thenyl, phenylalkyl having up to three carbon atoms in the alkyl moiety or benzoylmethyl, said phenylalkyl and benzoylmethyl being optionally mono or di-substituted in the phenyl ring by fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, or when two different substituents are present by chlorine, methyl, methoxy or trifluoromethyl. These particular compounds are useful in therapy as aldose reductase inhibitorsforthe control of certain chronic diabetic complications. Typical members include those compounds derived from 2-oxo-1-benzimidazolineacetic acid wherein a benzyl moiety is substituted at the 3-position of the molecule. Methods for preparing these compounds from known starting materials are provided.</p> |
