| 摘要 |
A process for the preparation of Citalopram comprising the transformation of a compound of formula (VII), wherein R is C1-C4 alkyl. Compound (VII) is reacted in sequence with a Grignard reagent of a 4-halo fluorobenzene and a Grignard reagent of a 3-halo-N,N-dimethylpropylamine, respectively, giving a compound of formula (V), wherein R is as defined above. (V) Is hydrolysed to a compound of formula (IV), which is converted to a 5-oxime (III) by means of hydroxylamine, submitted to cyclization and converted to the corresponding 5-cyano derivative, i.e. Citalopram. |
