摘要 |
[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia:whereinY1 and Y2 are independently selected from the group consisting of (CH2)n,-C(X)-NH-,-(CH2)n-C(X)-O-, and X is O or S;R1 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like;R2 is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like;"A" is a benzene ring fused with the pyridazine ring; andR3 is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.
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