| 摘要 |
<p>Spiro hydantoins of formula (I), their optical isomers, and their salts with mineral or organic bases, are new. R3 is H, lower alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, or acyloxyalkyl, or aralkyl; R1 and R2 are the same or different and are H, lower alkyl, CF3, or a spiroalkylene (II). X is -CH2-, -O-, -S-, or -NR3-; n and n1 are 1 to 3; A is the residue of a benzene ring which may be substd. by 1-3 of halogens, lower alkoxy, CF3, CF30, CF3S, sulphamoyl, methylamino, sulphonyl, or dimethylamino sulphonyl; Z is O,S, or NR3; the dotted line is an opt. double bond; with the proviso that R1 and R2 are not both H when Z is O or S. Aldose-reductase inhibitors, they are therefore useful in treating abnormal concns. of galacticol and sorbitol in galactosemic patients, such as modifications of capillary function, discorders of nervous conduction, and diabetic cataracts with loss of transparency of the crystalline lens.</p> |
