| 摘要 |
<p>The invention has disclosed 1,2,3-trihydroxy benzene and its derivatives or pharmaceutically acceptable salts of formula I for zinc ion metal-protease inhibition. These compounds are used for selective depressants of zinc ion metal-proteases such as MT1-MMP,gelatinase A, B and collagenase, matrilysins, metal-elastase or stromelysin-1. These depressants can be used to adjust many physiological or pathology courses which are concerned with MMPs, ADAMs, ADAM-TS such as vessel rebirth, wound healing, organ transplantation, fecundation course and reactivation capability, bone rebuilding and ache. They are used for treating cancer, cardiovascular diseases, arthritis, periodontal disease, multiple sclerosis, inflammation, adenomyosis, cornea ulcer, bacterial meningitis, diabetic syndrome, kidney diseases, nerve retrogression diseases, AIDS, bleb, anaphylaxis, adenomyosis, osteoporosis, asthma and so on. These blocking agents can be used for antisenescence, antibiosis, commercial manufacture addition agents of cell epimatrix, collagen product, cosmetics and make-up preparation. They can used for animals and other living bodies.</p> |
