| 摘要 |
NEW MATERIAL:A compound of formula I or its salt [R<1> is H, halogen, nitro, etc.; R<2> is H or OH; l is 1 or 2; A is (CH2)n-CHR<4> (R<4> is H or lower alkyl; n is l or 2), etc.; B is C(CH3)2CHCOOH, etc.]. EXAMPLE:6-[ 2-[ 7a,8,9,10,11,11a-Hexahydro-4-oxo-4H-pyrido( 3,2,1-jk )-carbazole-5-carboxamido ]-2-phenylacetamide ]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3,2,0]heptane-2-carboxylic acid. USE:Anti-bacterial agent effective to Gram-positive and Gram-negative bacteria. PROCESS:The compound 1 is prepared by reacting the compound 12 with a compound 11 obtained by the Schotten-Baumann reaction of a compound 2 with a compound 10 (R<14> is lower alkyl; X<2> is halogen). |
