| 摘要 |
1440634 Vincamone and vincanol RICHTER GEDEON VEGYESZETI GYAR RT 7 Dec 1973 [8 Dec 1972] 56873/73 Heading C2C Vincamone and/or vincanol having the Formula I in which Z is O (vincamone) or H, OH (vincanol) is/are prepared by oxidizing a compound of the Formula II in which R is H or C 1-5 alkyl, with an oxidizing agent in a solvent at an elevated temperature. When R is C 1-5 alkyl, vincamone is obtained, and when R is H, a mixture of vincamone and vincanol is obtained. This mixture can be resolved into its individual components or oxidized to form pure vincamone. The mixture (or pure vincamone) may also be reduced with a complex metal hydride to form pure vincanol or a mixture of vincanol and isovincanol, the isovincanol preferably being epimerized to form further vincanol. The starting material (II) may be in the form of its optically active isomers or in racemic form, and any resulting racemic or optically active isomers may be separated from each other. Compound (II) is resolved into its stereoisomers by diastereoisomeric salt-pair formation using dibenzoyl tartaric acid. |
