Antitumour and antibacterial anthracycline glycoside antibiotic - esp. 13-deoxy-carminomycin prepd. by aerobic fermentation of Streptomyces peucetius var. carminatus

摘要

New anthracycline glycoside cpds. are 13-deoxy-carminomycin (I) and its salts: (I) is an antitumour agent (e.g. IC50 against HeLa cells in vitro 3.2 mg/ml, compared with daunorubicin 9.6 mg/ml), and also has antibacterial activity against Gram-positive and Gram-negative bacteria (e.g. MIC vs. Staph. aureus 209P is 12.5 mu g/ml).