PROCEDIMIENTO PARA LA PREPARACION DEL 7-(AMINO-FENILACETAMIDO)-3-METIL-A3-CEFEM-4-CARBOXILATO DE PIVALOILOXIMETILO

摘要

Pivaloyloxymethyl 7-(alpha-amino-alpha-phenylacetamido)-3-methyl-DELTA 3-cephem-4-carboxylate hydrochloride (I) (pivcephalexine) is prepd. by the reaction of phenyl glycinyl chloride hydrochloride (II) on a cephem isocyanate (III). (I) is a known antibiotic. This process gives better yields and a purer product than known methods of making (I).