PREPARATION OF BIODEGRADEABLE MICROPARTICLES CONTAINING A BIOLOGICALLY ACTIVE AGENT

摘要

A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phas e, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.