METHOD OF PRODUCING 1,2-DIHYDORO-3H-PYRROLO/1,2-/PYRROL--1-CARBOXYLIC ACIDS SUBSTITUTED IN POSITION 5

摘要

Compounds of the formula: …… wherein Y is …… in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring,… R<1> is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R<1> substitution being at the ortho, meta or para positions of the aroyl group, and… R<2> is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms. …These compounds are used as intermediates for the preparation of the corresponding 1-carboxylic acid compounds by hydrolysis, the latter compounds being pharmaceutically useful.