| 发明名称 |
PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns biopharmaceutics and PEG conjugates of natural or recombinant urate oxidase (uricase). Uricase is bound covalently to poly(ethylene glycol) or poly(ethylene oxide) (both denoted as PEG), with average of 2 to 10 PEG threads are conjugated with each uricase sub-unit, and average molecular weight of PEG is approximately between 5 kDa and 100 kDa. ^ EFFECT: obtaining almost non-immunogenic PEG uricase conjugates preserving at least 75% of uricolytic activity of non-modified enzyme. ^ 44 cl, 12 ex, 17 dwg |
| 申请公布号 |
RU2349341(C2) |
申请公布日期 |
2009.03.20 |
| 申请号 |
RU20060107111 |
申请日期 |
2006.03.09 |
| 申请人 |
MAUNTEHN V'JU FARMAS'JUTIKEHLZ, INK.;DJUK JUNIVERSITI |
发明人 |
VILLIAMZ L. DEHVID;KHERSHFILD MAJKL S.;KELLI S'JUZEHN DZH.;SAJFER MARK DZH. P.;SHERMEHN MEHRRI R. |
| 分类号 |
A61K38/44;C12N15/09;A61K31/495;A61K35/407;A61K38/00;A61K47/48;A61P13/02;A61P13/12;A61P19/06;A61P43/00;C12N9/06;C12N11/08;C12R1/67 |
主分类号 |
A61K38/44 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
