Novel cephalosporin compounds, a process for the preparation thereof, pharmaceutical compositions containing the same and the use thereof as a therapeutic agent against a microorganism.

摘要

The present invention relates to cephalosporins of the formula <CHEM> wherein R<1> represents an aromatic or hetero aromatic group, R<2> and R<3> represents optionally substituted alkyl, aryl, or aralkyl, a heterocyclic group, or a group of the formula -OR<6>, wherein R<6> represents hydrogen, a salt forming cation optionally substituted alkyl, aryl, or aralkyl, or a heterocyclic group, or R<2> and/or R<3> represent(s) a group of the formula -NR<7>R<8>, wherein R<7> and R<8> represents hydrogen, optionally substituted alkyl or aryl or a cycloalkyl group, or R<7> and R<8> form a heterocyclic ring, or R<2> and R<3> form a heterocyclic ring, R<4> represents hydrogen, a salt forming cation, or an ester forming group, and R<5> repre-sents hydrogen, acyloxy, carbamoyloxy, optionally substituted pyridyl, or a group of the formula -SR<9>, wherein R<9> represents alkyl or a heterocyclic group, and salts thereof. The above cephalosporins show antibiotic properties.