发明名称 |
2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates. |
摘要 |
<p>Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via intermediates II und III: <CHEM> wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R<6> and R<7> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R<1> min is hydrogen or a protecting group; and R<a>, R<b> and R<c> are independently selected from alkyl, aryl and aralkyl.</p> |
申请公布号 |
EP0017992(A1) |
申请公布日期 |
1980.10.29 |
申请号 |
EP19800102076 |
申请日期 |
1980.04.18 |
申请人 |
MERCK & CO., INC. |
发明人 |
CHRISTENSEN, BURTON G.;JOHNSTON, DAVID B.R.;SCHMITT, SUSAN M. |
分类号 |
A61K31/397;A61K31/40;A61P31/04;C07C205/43;C07D205/08;C07D477/00;C07D477/04;C07D477/20;C07D498/04;C07D507/04;C07D507/06;C07D507/08;C07F7/10;(IPC1-7):07D487/04;07D205/08;61K31/40 |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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