| 摘要 |
3-(3-carboxy-4-hydroxypheny1)-4,5-dihydro-2-pheny1 benz (e) indole(I), useful as antiphlogistic agent and anodyne, was prepd. by reacting tautomer type N-ammonium salts(II; R1 and R2 are able to form pyrrolidino or piperidino ring by coupling with N atom; R1,R2=C1-6 alky1; X = Br, Cl) with 5-amino salicylic acid. Thus, the mixt. of 1-phenacy1-2-(1-pyrrolidino)-3,4-dihydronaphthalene hydrobromide 3.98g, 5-aminosalicylic acid 1.53g and acetic acid 10ml was refluxed for 15 min to give I.
|
