摘要 |
Title compds. (I; R = hydroxy, halogen, trihalomethyl, alkoxy, acyloxy, pyridine) useful as anodyne, were prepd. by reaction of II [R' = hydroxy, halogen, OM (M = alkali metal) and III(X = hydroxy, halogen, organosulfonyloxy; n = 1-3). Thus, 3.0 g 1-(P-chlorobenzoy1)-2-methyl-5-methoxy-3-indolyl acetic acid and 3.0 g thionyl chlorid were refluxed in 70 ml benzene for 3hr, and residue, 1.0 g 3-pyridine methano1 and 0.95 g triethylamine were reacted for 2 hr in THF to give 1-(P-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl acetic-3-pyridylmethyl ester.
|