| 摘要 |
NEW MATERIAL:Antibiotic PA-31088-IVof formula IV and its salt. USE:Medicines, animal drugs, and disinfectants having a great activity against beta- lactamase producing bacteria, and effective against Gram-positive and Gram- negative bacteria. PROCESS:A PA-31088-IV producing strain, e.g. Streptomyces tokunonensis sp. nov., is incubated in a nutrient liquid medium containing carbon and nitrogen sources, and inorganic salts, and if necessary vitamins or precursors, at a pH of 5.5-8.5 and 20-40 deg.C aerobically to give the objective substance. In mass production, the incubation is preferably carried out for 20-80hr by the submerged aeration culture method. |
