VERFAHREN ZUR HERSTELLUNG EINES TOLLWUTIMPFSTOFFES UND DANACH ERHALTENER IMPFSTOFF

摘要

A method for preparing a rabies vaccine wherein rabies viruses are multiplied in poultry embryos, the heads of the embryos are harvested and the cell extract containing the rabies antigens is separated therefrom for differential centrifugation and density gradient centrifugation, the separated antigen is further processed using conventional methods. This process results in a highly selective concentration of antigens and the production of viruses having a very high activity and freedom from contaminating proteins.