摘要 |
<p>Ibuprofen p-hydroxyphenylurea ester having the formula 11: was prepared from the free acid, ibuprofen ¢+2-(p-isobutyl-phenyl)propionic acid! (1). The ester 11 above has the anti-inflammatory activity of the free acid, but in contradistinction to it, it has a pleasant taste, suitable for oral administration such as uncoated tablets, suspensions or syrups, for the treatment of inflammatory conditions, particularly arthritis.</p> |